Apothecary Diaries has captured the hearts of many anime enthusiasts with its intricate blend of historical intrigue, mystery, and the fascinating world of herbal medicine. Set against the backdrop of an imperial palace, it follows the journey of Maomao, a brilliant young woman who becomes an imperial pharmacist. As Maomao uses her knowledge of herbs and medicine to uncover palace secrets and navigate the political web of court life, the series expertly combines elements of mystery, history, and character development.
For fans of Apothecary Diaries looking to dive into more captivating stories with similar themes, here are 10 anime that share its charm, from strong female leads and historical settings to mysteries that unfold in complex, fascinating worlds.
1. Ascendance of a Bookworm
In Ascendance of a Bookworm, we follow Myne, a modern-day book lover who is reincarnated into a medieval world where books are a luxury only the elite can afford. Determined to pursue her passion, Myne embarks on a mission to make books accessible to everyone, using her ingenuity and resourcefulness to navigate the societal challenges of her new world.
Like Apothecary Diaries, this anime features a strong, intelligent female protagonist who uses her knowledge and skills to improve her environment. Myne’s journey of self-reliance and her resolve to bring about change mirrors Maomao’s efforts to solve palace mysteries, making it a great pick for fans.
2. The Ancient Magus’ Bride
The Ancient Magus’ Bride blends the magical and supernatural in a way that fans of Apothecary Diaries will appreciate. The story centers around Chise Hatori, a girl sold into slavery who is purchased by a mysterious sorcerer named Elias. As she learns more about magic and her own powers, Chise navigates a world filled with mystical creatures and ancient magic.
This anime shares Apothecary Diaries‘s sense of wonder and mystery, with a focus on folklore, nature, and the mentor-student relationship. The combination of historical elements and magic gives both shows a similar enchanting vibe.
3. Spice and Wolf
Set in a medieval world with strong economic and trade themes, Spice and Wolf follows Lawrence, a traveling merchant, and Holo, a wolf deity with a sharp mind and playful spirit. Together, they embark on a journey through various towns, solving economic challenges and encountering supernatural beings.
Like Apothecary Diaries, this anime offers a slow-paced, intellectual narrative with a historical setting. Holo’s sharp wit and Lawrence’s merchant skills mirror Maomao’s keen problem-solving abilities, and both series feature rich world-building with a focus on the practical and mystical.
4. Mushishi
For fans of the ethereal and mystical elements in Apothecary Diaries, Mushishi offers a unique and contemplative viewing experience. The story follows Ginko, a “Mushi Master,” as he travels the world studying Mushi—ethereal creatures that exist alongside humans but often cause strange phenomena. Each episode is a self-contained story that explores the delicate balance between humans and nature.
Mushishi‘s quiet, reflective tone and its focus on the mystical forces in nature parallel the subtle magic found in Apothecary Diaries. Both shows also feature a protagonist who approaches problems with knowledge and careful observation.
5. Snow White with the Red Hair
Snow White with the Red Hair is a romantic fantasy series that centers around Shirayuki, a skilled herbalist with striking red hair. After escaping her kingdom to avoid being forced into marriage, she finds refuge in a neighboring kingdom, where she works as a court herbalist and forms a close bond with Prince Zen.
Much like Maomao in Apothecary Diaries, Shirayuki uses her herbal knowledge to solve problems and aid others, while also navigating courtly life and the political intrigue that comes with it. The blend of romance, strong character development, and a focus on medicine makes this a perfect recommendation for Apothecary Diaries fans.
6. Emma: A Victorian Romance
For those who enjoyed the historical elements of Apothecary Diaries, Emma: A Victorian Romance offers a beautifully crafted love story set in Victorian England. The anime follows Emma, a maid, and her relationship with William, a wealthy young man. As their love defies the rigid class structure of the time, the series explores themes of societal expectations and personal freedom.
Like Apothecary Diaries, Emma immerses viewers in a detailed historical setting, with a focus on character development and emotional depth. The elegance and grace of both series make them feel like timeless stories.
7. Jormungand
Jormungand may differ in tone from Apothecary Diaries, but it features an unconventional and powerful female lead in Koko Hekmatyar, an arms dealer navigating a dangerous world of espionage and warfare. With her sharp intellect and strategic thinking, Koko leads her team through a series of action-packed missions filled with intrigue.
Like Maomao, Koko is a capable woman who stands out in a male-dominated environment, using her knowledge and skills to survive and excel. While the themes in Jormungand are darker, the character-driven narrative and the emphasis on tactical problem-solving make it appealing for Apothecary Diaries fans.
8. The Case Study of Vanitas
For fans of the intricate mysteries in Apothecary Diaries, The Case Study of Vanitas provides a compelling blend of vampires and steampunk aesthetics. The story follows Vanitas, a vampire doctor, and Noé, a vampire, as they investigate a series of mysterious events linked to a cursed book.
This anime’s combination of supernatural mystery, complex characters, and historical elements makes it a fantastic choice for viewers who enjoyed the investigative nature of Apothecary Diaries. Both series keep audiences engaged with their intriguing plots and richly detailed worlds.
9. Rokka: Braves of the Six Flowers
Rokka: Braves of the Six Flowers is a fantasy anime that introduces six chosen heroes tasked with saving the world. However, when a seventh hero appears, the group must determine who the imposter is. This whodunit-style plot keeps viewers on the edge of their seats as the mystery unfolds.
Much like Apothecary Diaries, Rokka combines mystery with a rich fantasy setting, drawing viewers in with its suspenseful storytelling and unique characters. The sense of intrigue and the quest to uncover hidden truths make it an ideal watch for mystery lovers.
10. Violet Evergarden
For fans of character-driven narratives and emotional depth, Violet Evergarden offers a powerful story of self-discovery and healing. Violet, a former soldier, becomes an Auto Memory Doll, helping others express their emotions through letters while coming to terms with her own past.
The beautifully animated series is a poignant exploration of human emotions, much like the character development seen in Apothecary Diaries. Both anime feature protagonists on journeys of growth and self-understanding, making Violet Evergarden a deeply moving recommendation.
Conclusion: Dive Deeper Into Rich, Mysterious Worlds
Fans of Apothecary Diaries will find much to love in these 10 anime, which share similar themes of historical intrigue, strong female protagonists, and captivating mysteries. Whether you’re drawn to tales of self-discovery, mystical forces, or courtly intrigue, these series offer a rich tapestry of storytelling that will keep you enchanted and engaged. Each show provides a unique world filled with wonder, making them perfect companions to Apothecary Diaries.
For more like this read our blog on Top 10 Anime Delightful for 10-Year-Olds
